Frontline Plus for dogs is a topical medication that works against tick and flea infestations. Its active ingredients, S-Methoprene and Fipronil, work to not only kill all existing ticks and fleas, but also work on flea eggs and larvae to ensure that they do not mature into adults. This medicine is known to be 100% effective within the first 48 hours of its application. Apart from this, Frontline Plus is also preferred by many because of its long-lasting effect. Once applied, this medication can be effective for an entire month, even if you bathe your dog or take him swimming. This is because fipronil accumulates in the animal’s sebaceous glands, from where it is constantly released onto the skin and fur.

Frontline Plus for dogs is a safe medication and can be used in puppies and kittens as early as two days after birth. Although side effects of this medication are not common, they do sometimes occur and are mostly related to the alcohol used as a solvent.

Frontline Plus for Dogs: Side Effects to Watch Out For

If side effects occur after the use of Frontline Plus for Dogs, they will generally be related to effects on the skin. There are also side effects that have sometimes been seen to be neurological or mental in nature.

Skin Related Side Effects

An immediate reaction that your dog could have after the application of the medication is skin irritation. Itching and hair loss at the application site have also been reported in some dogs. Skin irritation usually manifests itself in the form of redness or discoloration of the skin and itchiness. Most of the time, the side effect is temporary and goes away in a few days. However, if the irritation does not subside or seems to be more severe than before, you should immediately consult your vet.

When skin irritation occurs, your dog will attempt to scratch the area. This will aggravate the condition. So keep an eye on your pet and avoid scratching, as scratching will spread the medication to their paws and other areas of their body, which they may lick off. Scratching could also cause the area to bleed, which in turn would cause the medication to enter the bloodstream.

Neurological Side Effects

Some of the neurological side effects could include:

  • increased drooling
  • Hypersensitivity to noise, light, or touch
  • Become quiet and appear depressed
  • Aggression and anxiety
  • fast heart rate
  • Breathing or respiratory effects
  • Panting and vomiting have also been seen in some dogs, although it passes quickly.

If you notice any of these symptoms persisting in your pet, see your vet immediately.

Frontline Plus for dogs: effects on humans and other species

Side effects in humans are rare. The most frequently reported effects are irritation of the skin, mouth and eyes. If this occurs, immediately wash the affected area with plenty of clean water. The best way to avoid this effect is to apply Frontline Plus for Dogs just before bed and allow the medication to dry completely overnight before cuddling the dog. Do not allow your dog to sleep on your bed after applying the medication. Although serious reactions are extremely rare, humans may experience vomiting, agitation, and seizures. If such effects occur, you should immediately consult your doctor.

Regarding its effects on other species, the first thing to remember is not to apply Frontline Plus for dogs to cats. This medication is specifically available for cats. This medication could be fatal to rabbits and aquatic species, so take care to prevent these species from coming into contact with the medication.

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